TP53 and cancer: Kim et al. [71] analyzed by NGS a series of cancer related genes during in vitro culture of human umbilical cord blood MSCs and found mutations occurring at P16 in NOTCH1 (NOTCH homolog 1), MLH1 (MutL homolog 1), GNAS (guanine nucleotide binding protein, alpha-stimulating activity) and TP53 (tumor protein 53) genes.