AHR and Shock: The AhR has been shown to have a crucial role in the regulation of pro-inflammatory responses activated by bacterial antigens, particularly lipopolysaccharide (LPS), since AhR deficiency in knockout mice promotes increased production of IL-1β, IL-6, IL-12, TNF-α, and IFN-γ after inoculation with LPS, promoting the development of septic shock [103].