INS and hyperinsulinism: In this study, the MOD group of rats developed hyperglycemia, dyslipidemia, hyperinsulinemia, insulin resistance and weight loss (Figure 1 and Figure 2), which agree with previous investigations [41,42], suggesting that the animal model of T2D with glucose and lipid metabolic syndrome was successfully established [43], and the occurrence of hyperinsulinemia may be due to resulting compensatory insulin release in the rats in the MOD group [42,44].