Other negative actors in the immune microenvironment of EOC are represented by up-regulated vascular endothelial growth factor (VEGF), a pro-angiogenic but also an immunosuppressive factor, and endothelin-B that reduces the permeability of tumoral blood vessels, the lymphocytes diapedesis and, as a consequence, their possibility to contrast the cancer cells [20]. Here, VEGFA is linked to cancer.