Notably, the eradication of the pericytes population from the TME might determine a wide range of destabilizing effects because of a partial decrease in tumor vasculature as it happens during the treatment with AX102 (an inhibitor of PDGF-β signaling) or in mice holding a mutation in the PDGF-β retention, causing a mild reduction in the number of pericytes [3]. The gene discussed is PDGFB; the disease is neoplasm.