The EGF/EGFR TAM-tumor cell crosstalk induces autocrine VEGF-C/VEGFR-3 signaling in tumor cells, which upregulates integrins and ICAM-1 necessary for maintaining cell-to-cell contact between tumor cells and TAMs (via CD11b/c) and stabilizing the tumor spheroids with (chemo)protective properties, as suggested by Freire et al. [62]. This evidence concerns the gene EGF and neoplasm.