In precancerous and in early stages of cancer HPV oncoproteins modulate the immune response via the inhibition of pro-inflammatory molecular cascade in keratinocytes, mainly reducing the expression of CCL2 also referred as monocyte chemoattractant protein 1 (MCP1) and CCL20, also known as macrophage inflammatory protein-3α (MIP3A) [10]. This evidence concerns the gene CCL2 and cancer.