Examples of polytherapy in current use include ventilatory support variously combined with antibacterial or antiviral therapy for associated infection, corticosteroids for a hypersensitivity component, vasopressors and/or blood transfusions for hypovolemia, etc. Since ALI due to any etiologic factor is likely to be associated with lung inflammation, the administration of PIP-2 could be an important adjunct to prevent the oxidative stress component of lung inflammation that is mediated by ROS release associated with activation of NOX2. This evidence concerns the gene CYBB and infection.