Examples of polytherapy in current use include ventilatory support variously combined with antibacterial or antiviral therapy for associated infection, corticosteroids for a hypersensitivity component, vasopressors and/or blood transfusions for hypovolemia, etc. Since ALI due to any etiologic factor is likely to be associated with lung inflammation, the administration of PIP-2 could be an important adjunct to prevent the oxidative stress component of lung inflammation that is mediated by ROS release associated with activation of NOX2. The gene discussed is CYBB; the disease is acute respiratory distress syndrome.