Previous studies found that the elevated plasma cancer markers (CA125, CA153, CA199, CEA, and alpha-fetoprotein) may associate with cerebral hemorrhage patients with cancer.[15,36] In present study, it was found that elevated plasma CEA and CA199 levels were the independent risks for cerebral hemorrhage in patients with active LC. Here, CEACAM5 is linked to laryngotracheoesophageal cleft.