CD274 and esophageal cancer: Some clinical trials reported that programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors alone have better application prospects than platinum-based chemotherapy.[12–18] We will conduct a systematic review and meta-analysis on the efficacy comparison between immunotherapy and traditional platinum-based chemotherapy, so as to provide a reliable basis for further promotion of immunotherapy and for clinicians to formulate the best chemotherapy regimen for patients with esophageal cancer after esophagectomy.