In addition, knockdown of either PARP7 or PARP10 mRNA mildly reduced gRNA production in cells infected with either WT or N1347A virus (Fig 5A), suggesting that they have pro-viral functions in MHV-infected BMDMs, perhaps analogous to alphavirus-infected cells but in contrast to other virus infection models where they are known to be antiviral [30, 38]. Here, PARP10 is linked to viral infectious disease.