CD4 and HIV-1 infection: The second major point is that the distribution of HIV-2 reservoirs among memory CD4 T cell subsets differ from the usual reservoir distribution observed in HIV-1 infection and suggest our working hypothesis of a limited reservoir in TCM is in line with what reported in the sootey-mangabey model of attenuated though productive SIVsm infection [49], as well as, with our own group’s description of a relative TCM subset protection in HIV-1 infected LTNPs bearing the protective HLA-B*27 or B*57 alleles [50] or in post-treatment HIV controllers [48].