In a previous study, 199 SGA patients treated with rhGH were followed-up for 5 years; both insulin resistance and beta cell dysfunction caused by rhGH have been resolved within 6 months post-treatment, and at the end of the follow-up period, body composition, insulin sensitivity and beta-cell function did not differ between the study group and the untreated controls [26]. This evidence concerns the gene INS and Insulin resistance.