Since the phagocytosis of Aβ protein by microglia/macrophages has been proposed as an Aβ-lowering mechanism in AD [38, 39], we wanted to see whether the observed increase in Iba-1 + cell number correlates with the increased colocalization of Aβ42 in microglia surrounding the plaques. This evidence concerns the gene AIF1 and Alzheimer disease.