APP and Anxiety: After 1 month of exposure to EE, the time spent in and the frequency of entry into the open arms were significantly increased in the APP/PS1 mice (time: APP/PS1 + SE, 44.82 ± 8.73 s; APP/PS1 + EE, 81.96 ± 15.02 s; p = 0.046; frequency: APP/PS1 + SE, 15.67 ± 2.27; APP/PS1 + EE, 38.44 ± 4.74; p = 0.004; Figure 1a), suggesting improved locomotor accompanied by less anxiety in the EE‐exposed APP/PS1 mice.