In the univariate analysis, the following factors were significantly correlated with OS: sex, HBV‐related HCC, cirrhosis, antiviral treatment, the presence of macrovascular and microvascular invasion, primary tumor size, BCLC stage, HCC recurrence, Axl expression in tumors and LC3 expression in tumors. This evidence concerns the gene MAP1LC3A and hepatocellular carcinoma.