However, under hyperglycaemia, SP1 siRNA, ROBO4 siRNA and miR‐125b‐5p could protect against HG‐stimulated RPE migration, and HIF‐1α siRNA, ROBO4 siRNA and miR‐146a‐5p could also prevent hypoxia‐induced RPE migration. The gene discussed is SP1; the disease is Hyperglycemia.