ROBO4 and Hyperglycemia: However, under hyperglycaemia, SP1 siRNA, ROBO4 siRNA and miR‐125b‐5p could protect against HG‐stimulated RPE migration, and HIF‐1α siRNA, ROBO4 siRNA and miR‐146a‐5p could also prevent hypoxia‐induced RPE migration.