Higher levels of TWEAK and Fn14 expression usually appear in response to stress, tissue damage, or remodeling; this expression can also occur in connection with many other disorders, including autoimmune diseases and cancers (Gu et al., 2013; Wang et al., 2017), triggering the activation of multiple downstream signaling pathways that can modify these tissues. This evidence concerns the gene TNFRSF12A and autoimmune disease.