CASP3 and acute kidney injury: Evidently, apoptosis in AKI is regulated by the balance of anti‐ and pro‐apoptotic proteins in the Bcl‐2 and caspase family,39 and activation of caspase 3 and caspase 8 is critical execution factors of caspase‐dependent apoptosis.40 It was also shown in this study that single exposure of cisplatin dramatically increased the protein levels of Bax, cleaved caspase 3 and cleaved caspase 8, while decreased Bcl‐2.