BNIP3,56 a mitochondrial pro‐apoptotic protein belonging to the Bcl‐2 family, is activated by the cisplatin‐induced damage of renal tubular epithelial cells and is considered as an adaptive response to pathogenetic oxidation in AKI.57, 58 Additionally, LC3‐I was accumulated in Cisplatin plus Rb3 groups ,and higher than that in cisplatin‐treated alone mouse kidney (shown in Figure 4A). This evidence concerns the gene BNIP3 and acute kidney injury.