As summarized in Figure 10, this research demonstrated, for the first time, the protective effects and the underlying mechanism of G‐Rb3 against cisplatin‐induced renal failure, through regulating AMPK/ mTOR signal pathway to restore antioxidant systems and to inhibit proximal tubular injury by suppression of ROS‐mediated apoptosis and autophagy. This evidence concerns the gene MTOR and Renal insufficiency.