MYCBP protein binds to proto‐oncogenes MYC to enhance the ability of c‐MYC protein‐promoted tumorigenesis.34, 35 The over‐expression of MYCBP promoted the invasion and migration of gastric cancer cells, and vice versa when inhibited.35 In addition, the MYCBP is a negative target of tumour‐suppressive miR‐22.36 Duan et al37 showed that the MYCBP is a target of tumour‐suppressive miR‐516b, and its down‐regulation promoted ameloblastoma cell apoptosis by inhibiting cell proliferation, migration and invasion through MYCBP/c‐myc/RECK/MMP signalling pathway. This evidence concerns the gene RECK and gastric cancer.