ACE and type 2 diabetes mellitus: In low-risk patients with T2DM (e.g., single vessel or two-vessel disease), the European Society of Cardiology (ESC) recommends treatment with initial optimal medical therapy including an angiotensin-converting enzyme (ACE) inhibitor, beta-blocker, aspirin, and statin reserving CABG for refractory symptoms since revascularization has not been shown to have a mortality benefit in these patients [4, 5].