INS and type 1 diabetes mellitus: For example, a population-based prospective cohort study done in the United States of America to determine risk factors for frequent and severe hypoglycemia in T1DM patients found in their multivariable analysis that lower HbA1c, intensive insulin therapy, and more frequent (3-4 times per day) SMBG were associated with increased risk of frequent (mild and moderate) hypoglycemic reactions whereas only lower HbA1C and older age were associated with severe hypoglycemic reactions [7].