This result indicates that there is no co-occurrence of deregulation of the chr7p12.2 imprinting control region and allelic switching of GRB10. We therefore conclude that while deregulation of the imprinting control region of GRB10 is a frequent event in CRC, deregulation is unrelated to the allelic switching of this gene. This evidence concerns the gene GRB10 and colorectal carcinoma.