For the first time in 2018, The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN, USA), separated treatment pathways for p16(+) and p16(−) OPSCCs [24]; however, recommendations for p16(+) and p16(−) OPSCCs are almost identical, with the only notable difference as follows: as an alternative to definitive radiation therapy (RT) alone or surgery alone, treatment with RT plus systemic therapy is a recommendation (category 2B) for T1 N1 p16-negative tumors, but is not recommended for p16-positive tumors until tumor size reaches T2 (with single node ≤3 cm). Here, CDKN2A is linked to neoplasm.