Cetuximab is a human-mouse chimeric IgG1 antibody against epidermal growth factor receptor (EGFR) that is FDA approved as a monotherapy for recurrent/metastatic HNSCC, in combination with radiation therapy for advanced HNSCC, and in combination with chemoradiation for recurrent/metastatic HNSCC [13]. Here, EGFR is linked to head and neck squamous cell carcinoma.