With the knowledge that salivary gland carcinomas express various potential targets such as the epidermal growth factor receptor (EGFR) [13, 14], c-kit [15], and human epidermal growth factor receptor-2 (HER-2) [16], numerous trials of biologic agents have been conducted since 2003 (Table 2). Here, EGFR is linked to salivary gland carcinoma.