CYLD and head and neck squamous cell carcinoma: Although all patients carrying the CYLD-mutated HNSCC tumors had advanced disease at the time of diagnosis [Stage III (2/8 cases) and Stage IV (6/8 cases)], the published TCGA cohort with only 8 CYLD-mutated cases was not able to reveal any CYLD-mutation and overall patient survival correlation (data not shown).