In this study, it demonstrated that PF could alleviate vascular injuries induced by hyperglycemia fluctuations in terms of the release of TNF-α, PECAM-1, oxidative stress, and the expression of PKCβ1 in HUVECs subjected to intermittent glucose levels and in DM rats with fluctuating hyperglycemia. Here, PECAM1 is linked to Hyperglycemia.