CTLA4 and neoplasm: In the 5T33 mouse model, tumor-bearing mice treated with low dose whole body irradiation and combinations of immune checkpoint blockade (PD-L1 blockade with LAG-3, TIM-3, or CTLA4 blocking antibodies) had not only significantly improved survival rates, but also correlated with increased frequency of tumor-reactive T cells and elevated levels of inflammatory cytokines [133].