However, CD4+ T cells do not proliferate to the same degree as CD8+ T cells [33, 35] leading to a reduction in CD4:8 in MM patients [28, 36], which could be partly explained by the higher expression of CD122 (the β-chain of the IL-2/IL-15 receptor) on CD8+ T cells [37] and increased availability of IL-15 in lymphopenic states [34]. Here, CD8A is linked to Miyoshi myopathy.