As we found no significant changes at the transcription level, our results suggest that FNDC1 and FNDC4 are not relevant factors in intestinal dysplasia, although we cannot exclude a role for (post)translational regulation of FNDCs. In the microsatellite-unstable colorectal cancer data set, FNDC4 was small but significantly downregulated. Here, FNDC1 is linked to colorectal cancer.