In addition, in vitro experiments have demonstrated that members of the miRNA-15 family, such as miRNA-15, miRNA-16, miRNA-195, miRNA-497 [66], and miRNA-26a [67], directly target other tau phosphorylation-associated genes (e.g., ERK1 and GSK-3β) to participate in the development of AD. This evidence concerns the gene MAPT and Alzheimer disease.