Tsenov et al. in 2007 [124] used intrahippocampal ET-1 injection to generate a model of ischemia-induced seizures in immature rats, at P12 and P25, respectively, showing that at both developmental ages, ET1 into the dorsal hippocampus elicited convulsions as well as neuron loss. The gene discussed is EDN1; the disease is ischemia.