The augment effect of IL-27 using recombinant IL-27 inhibited macrophage activation and attenuated atherosclerosis, while blockade of IL-27/IL-27R using EBI3-deficiency mice and transplanting IL-27Rα−/− bone marrow to LDLR-/- mice induced the Th17 immune response and aggravated atherosclerosis, indicating a protective role of IL-27 in atherosclerosis [27, 37]. The gene discussed is EBI3; the disease is atherosclerosis.