Based on the statistical comparison significant contribution to the outcome is revealed for age (odds ratio of 1.1, p = 0.0366), PSA (odds ratio of 1.2, p = 0.0162) and the 19-biomarker model (odds ratio of 2.2, p < 0.0001), while the presence and number of previous biopsies, prostate volume and the result of DRE were not significant predictors of Sig PCa. The gene discussed is KLK3; the disease is posterior cortical atrophy.