In line with this and in order to facilitate comparisons, an additional prospective validation study design is planned, similar to other studies, such as the step approximation of the STHLM3 study, which was able to identify up to 21% of Sig PCa in patients with a PSA between 1 and 3 ng/ml.35 In the prospective evaluation, inclusion of multiparametric magnetic resonance imaging is planned, as it has demonstrated an added value in the diagnostic approximation for Sig PCa with a high NPV, improving the detection of Sig PCa.36,37. The gene discussed is KLK3; the disease is posterior cortical atrophy.