The three remaining peptide markers were a fragment of protein phosphatase 1 regulatory subunit 3A, which was identified with decreased abundance and fractalkine or chemokine (C-X3-C motif) ligand 1 and Semaphorin-7A, both upregulated in the group of patients with Sig PCa. The gene discussed is PPP1R3A; the disease is posterior cortical atrophy.