As the accumulation of excess FAs can induce lipotoxicity, which might be especially important during the periods of hypoxia when FA uptake is upregulated, storage of excess FAs in lipid droplets through inhibition of PNPLA2-mediated lipolysis would constitute a conceivable strategy for cancer cells to evade lipotoxicity during hypoxic conditions. This evidence concerns the gene PNPLA2 and cancer.