PNPLA2 and cancer: Zhang et al.32 observed that intracellular lipolysis mediated by patatin-like phospholipase domain containing 2 (PNPLA2) [commonly known as adipose triglyceride lipase (ATGL)] is significantly reduced under hypoxic conditions.32 This lipolytic inhibition contributes to the accumulation of TGs and lipid droplets and cancer cell survival.