SCD and prostate carcinoma: Interestingly, it was shown that SCD inhibition is only detrimental to prostate cancer cell survival (in vitro) in the absence of exogenous lipids, particularly oleic acid.60 However, silencing of SCD reduces tumour growth in xenograft models of lung,63 gastric50 and liver cancer64, and also inhibits orthotopic growth of prostate cancer cells in vivo.60 Taken together, these studies suggest that unsaturated lipids are indeed limited within the tumour microenvironment.