Upon demand, fatty acyl moieties can be released from these stored TG deposits in lipid droplets via an intracellular lipolytic pathway (Fig. 1; Intracellular Lipolysis).55 Zechner et al.55 showed that monoglyceride lipase (MGLL) provides, by de-esterification, a stream of intracellular free FAs that can fuel cancer cell proliferation. The gene discussed is MGLL; the disease is cancer.