Thus, as SOD1 is down-regulated in absence of its substrate (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${{\rm{O}}}_{2}^{\cdot -}$$\end{document}O2⋅−), expression of pAKT as well as NFĸB (p65) is not detected in hypo-thyroidism. The gene discussed is SOD1; the disease is thyroid gland disorder.