TASL and systemic lupus erythematosus: The remaining two SNPs, rs2429517 and rs2429518, are located in the downstream intergenic region of CXorf21. The associated haplotype is distinctly separated from neighbouring haplotypes by high recombination (D′ < 0.6, r2 < 0.2) and accordingly, the risk haplotype itself represents the only observed association with SLE (χ2 = 29.87, P = 4.63 × 10−8; χ2 test; Fig. 1d).