VWF and neoplasm: It is evident that a deficiency of vWF causes a number of diseases; however, increased plasma levels of other cargo stored in WPBs are reported in cardiovascular and neoplastic diseases, and in the aging population they contribute to an increased risk of thrombosis (Lerman et al., 1991; Vischer, 2006; Alfonso and Angiolillo, 2013; Korhonen et al., 2016; Schuldt et al., 2018).