In conclusion, a GWAS was conducted in AAs with T2D-ESKD and seven genetic loci displayed genome-wide significant evidence of association, including in RND3/RBM43, SLITRK3, ENPP7, GNG7, APOL1, GRAMD3, and MGAT4C. Beyond APOL1, EFNB2 and GNG7 were also associated with non-diabetic ESKD and revealed genome-wide significant association with all-cause ESKD. Here, GRAMD2B is linked to type 2 diabetes mellitus.