In the APOL1-negative model, in addition to replicating ENPP7 identified in the baseline model, two novel loci achieved genome-wide significant association with T2D-ESKD: GRAMD3 (rs75029938; P = 2.02 × 10−9) and MGAT4C (rs17577888; P = 3.87 × 10−8). This evidence concerns the gene ENPP7 and type 2 diabetes mellitus.