In all, seven genome-wide significant loci (P < 5 × 10−8) associated with T2D-ESKD were identified in either the baseline model (RND3/RBM43, SLITRK3, ENPP7, GNG7, and APOL1) or APOL1-negative model (ENPP7, GRAMD3, and MGAT4C). The gene discussed is ENPP7; the disease is type 2 diabetes mellitus.