In contrast, TNC overexpression is found in a variety of disease states and multiple cancers, including adult and pediatric supratentorial high grade glioma (HGG) [7, 8, 56, 65] and pediatric ependymoma [2], as well as breast [11, 19], non-small cell lung [37], colorectal [21], and pancreatic cancers [57]. Here, TNC is linked to central nervous system cancer.