TNC and central nervous system cancer: First, we found statistically significantly increased TNC expression in DIPG tumor tissue compared to normal brain tissue from the same patient (Fig. 1a), and validated these findings via immunohistochemical staining of a large cohort of pediatric glioma tissue specimens (n = 50, Tables 2 and 3) and mouse xenograft tumors generated with DIPG cell line SF8628 (Fig. 1b).