Moreover, since MIIP was able to negatively regulate AKT-mTOR signaling in both PTEN-deficient PCa cell LNCaP,C4–2 and PC3 and in PTEN-intact 22Rv1 cells (Fig. 3a and b), we concluded that PTEN is not a critical mediator in this process. This evidence concerns the gene PTEN and posterior cortical atrophy.