Serum anti-MPO and P-ANCA were weakly positive, while other indicators including antinuclear, anti-SSA, anti-SSB, anti-dsDNA, anti-Sm, anti-RNP, anti-Scl-70, anti-RP3, anti-GBM, anti-neutrophil cytoplasmic antibodies in cytoplasmic, antibodies to neuro-paraneoplastic syndromes, neuromyelitis optica (NMO), myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) in blood as well as cerebrospinal fluid (CSF) were negative. Here, RNPC3 is linked to neuromyelitis optica.