The Risk Evaluation of Viral Load Elevation and Associated Liver Disease (REVEAL) study, which followed more than 3500 untreated CHB patients in Taiwan for a mean duration of 11 years, demonstrated that higher levels of HBV viral load, elevated alanine aminotransferase (ALT), older age, and male sex were independent predictors of cirrhosis and HCC [7, 8]. This evidence concerns the gene GPT and Cirrhosis.