For instance, as demonstrated by the current study, the upmodulation of PTEN signaling was beneficial in the attenuation of CAL-induced ventricular hypertrophy and HF, but the loss of PTEN prevented ventricular hypertrophy in response to the pressure overload by aortic banding in the experiment conducted by Oudit et al. (46). The gene discussed is PTEN; the disease is hydrops fetalis.