There was no significant difference among the 4 groups (PNET/ NSCLC/benign/healthy volunteers) in terms of CgA and SCCA1 values, but the difference in the ProGRP, NSE, and adjusted NSE values was found to be statistically significant (ProGRP, P = 0.006; NSE, P = 0.015; adjusted NSE, P = 0.09). This evidence concerns the gene CGA and primitive neuroectodermal tumor.