Given the significant role of tyrosine kinase receptors [67,68], downstream signaling of the SRC-ERK [23] pathway in the development of melanomas and their resistance to anticancer drugs and the RNA-seq sequencing results supporting the participation of SIRT2 in the regulation of these pathways, we confirmed that EGFR and EPHA2 receptors were downregulated in cells with low SIRT2 expression (Figure 5a,b and Figure 6a,b and Figure S1b). This evidence concerns the gene EGFR and melanoma.