Similarly, genes related to melanoma invasion were downregulated in SIRT2-deficient melanoma cell lines (e.g., HLA-DRA, IL-6, CD74, and HLA-DRB1 in the SSW30 clone, Dataset S1; PTPRZ1, FST, and NRCAM in the SSM15 clone, Dataset S2). This evidence concerns the gene HLA-DRA and melanoma.