Whatever the mechanism, these results further support the predictive model of CEP290-associated pathogenesis and it would be tempting to correlate the severity of the retinal disease of P2 compared to P1 (congenital blindness vs. measurable VA of 20/67 (RE) and 20/50 (LE) at 20 years, respectively) to a reduced abundance of CEP290∆36aa product in photoreceptor cells. Here, CEP290 is linked to congenital stationary night blindness.