Along with this, co-treatment with the respective ODN negative controls (ODN 2006c, M362c, and 2216c) did not lead to significantly higher tetramer staining, cancer cell cytotoxicity, or cytokine expression as compared to the peptide treatment alone, suggesting the specificity of ODN towards MamA2.1 specific CD8+T cell activation. The gene discussed is CD8A; the disease is cancer.