HDAC3 and melanoma: Human melanoma cell lines have been inhibited by Rg3 through the down-regulation of histone deacetylase 3 (HDAC3) and the up-regulation of p53 acetylation [61] in addition to the decrease of fucosyltransferase IV (FUT4) and its synthetic product Lewis Y (LeY) FUT4/LeY expression and the inhibition of EGFR/MAPK pathway activation [62].