E2F8 and small cell lung carcinoma: On the other hand, these studies showed that OOS provoked the up-regulation of E2F8 (fold change: 2.44, p-value: 0.03), CDKN2A (fold change: 1.6, p-value: 0.018), and CDKN2C (fold change: 2.25, p-value: 0.022) in SCLC tumors (Figure 3B, D).