PRKN and Parkinson disease: Altered expression of genes encoding proteins involved in mitochondrial homeostasis [e.g., Parkin, PTEN-induced putative kinase 1 (PINK1), DJ-1, leucine-rich repeat kinase 2 (LRRK2), ATPase 13A2, vacuolar protein sorting-associated protein 35 (VPS35) is also linked to PD [46].