In a meta-analysis from 2008, n-3 PUFA supplementation in people with T2D had no significant effect on glycemic control [23], whereas vegetable PUFAs were found to reduce fasting insulin and Homeostasis Assessment Model-Insulin Resistance (HOMA-IR) in a more recent meta-analysis in healthy subjects [24]. The gene discussed is INS; the disease is type 2 diabetes mellitus.