SV-LEC co-culture with tumor-educated macrophages led to a reduction in Tau of the biosensor from 1.797 ns ± 0.0252 ns to 1.622 ns ± 0.0338 ns, indicating an increase in FRET between the GFP- and RFP-terminal fluorophores and, consequently, an increase in RhoA activity (Figure 2G). The gene discussed is RHOA; the disease is neoplasm.