PTPRC and neoplasm: Primary LECs had a mean spread area of 1,132 μm2 ± 247.9 μm2, which reduced slightly to 808.6 μm2 ± 185.9 μm2 after the addition of endogenous uneducated macrophages but dramatically reduced to 324.1 μm2 ± 76.43 μm2 with tumor-educated macrophages and 473.7 μm2 ± 92.8 μm2 with ex vivo TAMs (CD45+Ly6G−CD31−CD11b+).